CARNEGIE CAREER COLLEGE Main Campus Location: 1292 East Waterloo Road, Mogadore, Ohio 44260 (330) 628-1532


OPIATE TREATMENT PROGRAMS

Objective: The student will acquire an understanding of opiate treatment programs and be able to describe the various accepted types of treatment programs and the advantages and disadvantages of each treatment program including, Methadone, Buprenorphine, Buprenorphine- Naloxone, Clonodine, and Lofexidine. The student will be able to list the negative side effects and dangers apparent in each program.

Note: This training is a supplement to the training for chemical dependency counselors and it is understood that administration of medication is within the scope and approval of the medical supervisor of programs. Chemical dependency counselors must understand the various pharmacology treatment programs, but do not administer medication. This information is for educational purposes only.

METHADONE TREATMENT

Methadone is a synthetic narcotic analgesic, patented in 1941 by a German company. The drug was originally used as an analgesic and for withdrawal from heroin. It is still use for these purposes. As a maintenance program, methadone has several advantages; when administered in a single dose, it lasts between 24-26 hours without creating euphoria, sedation, or analgesia. This allows the patient to perform mental and physical tasks without impairment. The methadone reduces the consistent “hunger” for the drug which is a possible contributor to relapse. The medicine also creates cross- tolerance, and in this way blocks the effects of normal street doses of opioids such as heroin. Research studies have revealed that patients with doses of 60 mg per day or more resulted in better treatment outcomes than with lower doses. The dosage levels must be determined individually with consideration of the patient’s metabolism, body weight, duration of heroin use, and most importantly, maintenance of appropriate methadone blood levels over a 24 hour period.
The side effects reported with methadone include; tolerance within 4-6 weeks, but some symptoms can persist longer, such as constipation, sexual energy (libido), and sweating. Therefore it is essential for the counselor to monitor and report to the physician side effects so the physician can monitor the patient’s problems with compliance. Methadone prescribed in higher doses (up to 150 mg per day) on a long term basis has not proved to be toxic or to increase side effects. Patient’s may also experience periodic skin rash, weight gain, and water retention. Problems with irregular menses or amenorrhea are reported.

In the United States, methadone maintenance programs are strictly regulated by the federal and sate governments, the Food and Drug Administration (FDA) and the Drug Enforcement Agency (DEA).
Admission into a methadone maintenance program by federal standards requires the following:
1. A minimum of 1 year of addiction to opiates as well as current evidence of addiction (but there are allowances for pregnancy and recent discharge from a chronic care facility or prison).
2. The minimum age for entry is 18 years, or younger with parental or legal guardian consent. Applicants younger than 18 years, must have at least two prior documented treatment episodes, either short term detoxification or drug-free treatment, before they can be enrolled.

In the United States, most methadone programs have three stages:
1. Stage 1: Stabilization stage- This stage lasts approximately 3 months during which the patient adjusts to the medication. This stage is characterized by a thorough psychosocial history and assessment, and physical examination. The patient is oriented into the program and provided with all related issues of program compliance, rules, and how to deal with crisis situations. New patients must report to the program daily (6 or 7 days per week) during this stage.
2. Stage 2: Review stage- During this stage, the patient is subjected to a review and modifications of the treatment plan, Take home medication may be issued depending on compliance issues. Counseling issues, vocational and educational goals are provided and reviewed.
3. Stage 3: Continued maintenance stage- The patient is monitored for compliance and there may be a reduction of adjunctive services. Continued submission of urine specimens is required fro drug screening and to ingest a dose of methadone under observation, and continued consultation as desired, with program staff.

Other Issues for Medical and Counseling Staff:
1. Studies have revealed a reduction of HIV acquisition when on continuous methadone treatment programs. Issues of tuberculosis, and especially treatment resistant tuberculosis and an increase in hepatitis C has been occurring, and hepatitis C is expected to supersede the death rates of HIV in the future.
2. Alcohol and cocaine (crack and cocaine hydrochloride) have been reported as major substance abuse alternatives among patients on methadone maintenance.
3. Reductions in criminal activity have been reported among methadone maintenance patients.
4. The majority of reported deaths among methadone patients is due to poly-drug abuse involving other psychoactive substances. 

 
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BUPRENORPHRINE TREATMENT

Buprenorphrine is a derivative of the morphine alkaloid thebaine and has been available in the United States since the 1980s. As an analgesic, buprenorphine is 25-50 times more potent than morphine. Studies have revealed that buprenophrine can substitute for other opioids and to decrease illegal opioid use. Patients in the treatment program may be inducted onto therapy using either buprenophrine or buprenophrine- naloxone combination. Initial doses of buprenophrine will range from 4- 8 mgs per day, and in the buprenophrine- naloxone combination, the ratio of buprenophrine to naloxone is 4-1. Administering the first day’s dosage as to or three individual does may be useful, and dosages on subsequent days are then gradually increased to the desired level.

Adverse effects of buprenophrine are related to sedation, drowsiness, constipation, and tolerance to these effects are likely to occur with continued use. Deaths related to buprenophrine have been related to combining drugs with other central nervous system depressants such as benzodiazepines.

NON-OPIOID TREATMENTS: CLONIDINE AND LOFEXIDINE

Clonidine is useful in the medical detoxification of patients from methadone, as well as from other commonly abused opioids. Clonidine has been reported as useful in decreasing withdrawal symptoms related to alcoholism and nicotine. It also relieves withdrawal related effects such as lacrimation (“tearing”)and rhinorrhea (“runny nose”). It seems to be most effective in reducing withdrawal symptoms such as restlessness and diaphoresis (“increased perspiration”). It is not as well accepted by addicts because it does not produce morphine-like effects or relieve certain types of withdrawal distress, such as anxiety and hypotension (low blood pressure).

OPIOID ANTAGONISTS

Opioid antagonists help addicts to reduce the potential for relapse by occupying opioid receptor sites and blocking the effects of agonists at the cellular level. Purer opioid antagonists such as naltrexone which was developed in 1963. The medicine is well absorbed in the gastrointestinal tract and has antagonists activity for up to 72 hours after oral ingestion. Unfortunately, naltrexone treatment has a high drop-out rate (up to 80%). The drug does prevent addicts from getting “high”. Studies have found that subjects in programs with naltrexone and counseling have remained in treatment longer than those on naltrexone alone. Long term use of naltrexone has not proven to be harmful.

References:

Amato, L., Davoli, M., Minozzi, S. et al. Methadone at tapered doses for the management of opioid withdrawal. Cochrane Database System Review, 2005, (3) CD003409.

Charney, D.S., Riordan, C.E., Kleber, H.D. et al. Clonodine and naltrexone; A safe, effective, and rapid treatment of abrupt withdrawal from methadone therapy. Archives of General Psychiatry, 1982, 39, 1327-1332.

Strain, E.C. & Stitzer, M.L. The treatment of opioid dependence. Baltimore: John’s Hopkins University Press, 2006.

Strain, E.C. Clinical use of buprenorphine. In, Strain, E.C. & Stitzer, M.L. The treatment of opioid dependence. Baltimore: Johns Hopkins University Press, 2006, 230-252.